Resumen
In this paper, we propose two new response-adaptive designs to use in a trial comparing treatments with continuous outcomes. Both designs assign more subjects to the better treatment on average. The new designs are compared with existing procedures and the equal allocation. The power of the treatment comparison is assessed.

Resumen
Despite its importance, there has been little attention in the modeling of time series data of categorical nature in the recent past. In this paper, we present a framework based on the Pegram's [An autoregressive model for multilag Markov chains. Journal of Applied Probabability 17, 350–362] operator that was originally proposed only to construct discrete AR(p) processes. We extend the Pegram's operator to accommodate categorical processes with ARMA representations. We observe that the concept of correlation is not always suitable for categorical data. As a sensible alternative, we use the concept of mutual information, and introduce auto-mutual information to define the time series process of categorical data. Some model selection and inferential aspects are also discussed. We implement the developed methodologies to analyze a time series data set on infant sleep status.