Resumen
Since DNA sequences have no commas or spaces, frame synchronization, a property referred to as comma-freeness, is ideal for DNA code words. While no systematic construction has been developed for a binary comma-free, error-correcting code of large minimum distance, for the quaternary DNA sequence there exists a simple construction, the template method. Since annealing is essentially a physical, probabilistic process, unwanted annealing and subsequent DNA editing can occur at a stretch of completely matching DNA base-pairs. To avoid this, no subword of length-7 or 8 should appear in the designed words and their concatenations more than once. In the template method, this constraint is separately assigned to the template and the error-correcting code words.