The article focuses on the most crucial issues on transmission control protocol (TCP) and radio link control (RLC) interaction, including some practical development approaches, based on the optimum parameter configuration at the transport and link layers. TCP is the most dominant transport protocol for Internet applications that suffers severe performance degradation due to packet losses when a wireless link is present in the end-to-end path. With this, the third generation entity has been developed to define a reliable link layer protocol, RLC, to support packet switched services over Universal Mobile Telecommunications System. RLC provides error recovery in the radio access network by means of an Automatic Repeat Request algorithm.