We analyze the integral points on varieties defined by one equation of the form f₁ … f_r = g, where the f_i , g are polynomials in n variables with algebraic coefficients, and g has "small" degree; we shall use a method that we recently introduced in the context of Siegel's Theorem for integral points on curves. Classical, very particular, instances of our equations arise, e.g., in a well-known corollary of Roth's Theorem (the case n = 2, f_i linear forms, deg g < r - 2) and with the norm-form equations, treated by W. M. Schmidt. Here we shall prove (Thm. 1) that the integral points are not Zariski-dense, provided &Sum; deg f_i > n · max ( degf_i) + deg g and provided the f_i, g, satisfy certain (mild) assumptions which are "generically" verified. Our conclusions also cover certain complete- intersection subvarieties of our hypersurface (Thm. 2). Finally, we shall prove (mm. 3) an analogue of the Schmidt's Subspace Theorem for arbitrary polynomials in place of linear forms.