Resumen
The article focuses on software intensive systems on which modern society is dependant someway or the other. For the first time, electronic voting technology was used in the U.S. Presidential elections of November 1994. They are an example of the software-intensive systems that every industrialized society increasingly depends on for their basic operations. The systems can be availed in air travel, operating the electric power grid, and filing tax returns. The software-intensive systems are so complex that often it is difficult to understand and control them. Living in a world in which the number and diversity of devices, amount of software, and degree of connectivity in complex systems are all increasing by orders of magnitude, it is essential to have a science of design on which to base the efforts to create these systems. A scientific basis exists for many engineered artifacts, ranging from integrated circuits to airplanes. A more complete definition of a science of design may be found through close examination of the words "science" and "design."

Resumen
The article focuses on the role of Biogrids in the delivery of health care and in the understanding of evolutionary processes. Biogrids are increasingly important in the development of new computing applications for the life sciences and in providing immediate medical benefits to individual patients and even to those only at risk of getting sick. The development of targeted grids providing practical solutions to individual problems is also important in the overall development of grid technology, providing immediate, visible rewards from the continuing investment. The article explores four grid projects designed for specific biomedical issues: the SARSGrid for a global medical emergency; the eScience Diagnostic Mammography National Database project to develop a grid-enabled database of annotated mammograms; a temporary global grid constructed as a demonstration project to analyze arthropod evolution called the GliederfüsslerGrid; and the Biomedical Informatics Research Network devoted to neurology.